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The Sound of Evolution
Actinomycin D/Dactinomycin
Mechanism of action:
Actinomycin D primarily acts by intercalating into guanine-cytosine (G-C) base pairs within the double-stranded DNA structure. This inhibits RNA polymerase activity, blocks RNA synthesis, and indirectly interferes with protein production.
Reference(s):
Wang X et al. (2003). Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors. Mol Pharmacol.
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