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The Sound of Evolution
Alprazolam
Mechanism of action:
Alprazolam is a benzodiazepine derivative. It binds to the benzodiazepine binding site on GABA_A receptors in the central nervous system, thereby enhancing GABAergic inhibitory activity. When GABA binds to these receptors, chloride ion (Cl⁻) channels open, causing neuronal membrane hyperpolarization and reducing neuronal excitability, which in turn decreases excessive activation in the limbic system and cerebral cortex.
Reference(s):
Greenblatt DJ et al. (1993). Clinical pharmacokinetics of alprazolam. Therapeutic implications. Clin Pharmacokinet.
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