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Atomoxetine


Mechanism of action:

Atomoxetine is a selective norepinephrine reuptake inhibitor. It selectively inhibits the norepinephrine transporter on presynaptic nerve terminals, preventing norepinephrine reuptake and increasing its concentration in the synaptic cleft. This enhances norepinephrine-mediated regulation of neural circuits in the prefrontal cortex that are involved in attention and impulse control.

Reference(s):

1. Yu G et al. (2016). Atomoxetine: A review of its pharmacokinetics and pharmacogenomics relative to drug disposition. J Child Adolesc Psychopharmacol. 


2. Hutchison SL et al. (2016). Efficacy of atomoxetine in the treatment of attention-deficit hyperactivity disorder in patients with common comorbidities in children, adolescents and adults: a review. Ther Adv Psychopharmacol. 


3. Aman MG et al. (2014). A review of atomoxetine effects in young people with developmental disabilities. Res Dev Disabil.

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