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The Sound of Evolution
Azithromycin
Mechanism of action:
Azithromycin is a macrolide antibiotic that acts on the bacterial 50S ribosomal subunit. It binds near the exit tunnel region of 23S rRNA and blocks peptide chain elongation, thereby inhibiting bacterial protein synthesis and leading to bacterial growth arrest.
Reference(s):
1. Noedl H et al. (2006). Azithromycin combination therapy with artesunate or quinine for the treatment of uncomplicated Plasmodium falciparum malaria in adults: a randomized, phase 2 clinical trial in Thailand. Clin Infect Dis.
2. Peters DH et al. (1992). Azithromycin: a review of its antimicrobial activity, pharmacokinetic properties and clinical efficacy. Drugs.
3. McMullan BJ et al. (2015). Prescribing azithromycin. Aust Prescr.
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