The Sound of Evolution
Cefdinir
Mechanism of action:
Cefdinir is a third-generation oral cephalosporin antibiotic. The β-lactam ring of Cefdinir can bind to bacterial penicillin-binding proteins (PBPs), inhibiting their transpeptidase activity and preventing peptidoglycan chains from cross-linking. As a result, the bacterial cell wall becomes structurally weak, and the bacterium eventually undergoes lysis and dies due to osmotic pressure.
Reference(s):
1. Kimura Y et al. (2001). Successful steroid therapy for cefdinir-induced acute tubulointerstitial nephritis with progressive renal failure. Intern Med.
2. Perry CM et al. (2004). Cefdinir: a review of its use in the management of mild-to-moderate bacterial infections. Drugs.
3. Guay DR et al. (2000). Pharmacodynamics and pharmacokinetics of cefdinir, an oral extended spectrum cephalosporin. Pediatr Infect Dis J.