The Sound of Evolution
Ciclopirox
Mechanism of action:
Ciclopirox is a hydroxypyridone derivative. Ciclopirox forms stable chelates with multivalent metal ions such as ferric ions (Fe³⁺) and aluminum ions (Al³⁺). These metal ions are essential cofactors for many fungal metalloenzymes. When these metal ions are chelated by ciclopirox, fungal metabolism and cell membrane function are disrupted, ultimately leading to cell death.
Reference(s):
1. Niewerth M et al. (2003). Ciclopirox olamine treatment affects the expression pattern of Candida albicans genes encoding virulence factors, iron metabolism proteins, and drug resistance factors. Antimicrob Agents Chemother.
2. Sigle HC et al. (2005). Oxygen accessibility and iron levels are critical factors for the antifungal action of ciclopirox against Candida albicans. J Antimicrob Chemother.