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Dicloxacillin


Mechanism of action:

Dicloxacillin is a β-lactam antibiotic. Its β-lactam ring binds to penicillin-binding proteins (PBPs) in bacteria and inhibits their transpeptidase activity, preventing cross-linking of peptidoglycan chains. As a result, the bacterial cell wall becomes structurally weakened, and the bacteria ultimately rupture and die due to osmotic pressure.

Reference(s):

Williamson R et al. (1980). In vivo interaction of beta-lactam antibiotics with the penicillin-binding proteins of Streptococcus pneumoniae. Antimicrob Agents Chemother.

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