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The Sound of Evolution
Dicyclomine/Dicycloverine
Mechanism of action:
Dicyclomine is a muscarinic acetylcholine receptor antagonist. It binds to M₃ receptors on gastrointestinal smooth muscle, blocking the action of acetylcholine at these receptors. This suppresses calcium influx and contractile responses in intestinal smooth muscle, thereby reducing gastrointestinal motility, spasms, and glandular secretion.
Reference(s):
1. Danhof I et al. (1967). Metabolic dynamics of dicyclomine hydrochloride in man as influenced by various dose schedules and formulations. Toxicol Appl Pharmacol.
2. Walker BJ et al. (1987). Quantitative analysis of dicyclomine in human plasma by capillary gas chromatography and nitrogen-selective detection. J Chromatogr.
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