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The Sound of Evolution
Guaifenesin/Glyceryl guaiacolate
Mechanism of action:
Guaifenesin currently has an unclear molecular mechanism. It is only known to increase the water content of respiratory secretions, making thick mucus less viscous and reducing its adherence to the walls of the respiratory tract.
Reference(s):
1. Thompson GA et al. (2016). Guaifenesin Pharmacokinetics Following Single-Dose Oral Administration in Children Aged 2 to 17 Years. J Clin Pharmacol.
2. Kagan L et al. (2009). Effect of mode of administration on guaifenesin pharmacokinetics and expectorant action in the rat model. Pulm Pharmacol Ther.
3. Keshavarz M et al. (2013). Anticonvulsant Effect of Guaifenesin against Pentylenetetrazol-Induced Seizure in Mice. Iran J Med Sci.
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