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The Sound of Evolution
Kanamycin
Mechanism of action:
Kanamycin is an aminoglycoside antibiotic. It binds to 16S rRNA on the bacterial 30S ribosomal subunit, causing the ribosome to misread mRNA codons. This disrupts translation or leads to the production of abnormal, nonfunctional proteins, ultimately resulting in bacterial death.
Reference(s):
1. Stavropoulos TA et al. (2001). Synergy between tetA and rpsL provides high-stringency positive and negative selection in bacterial artificial chromosome vectors. Genomics.
2. Gondo Y et al. (1996). A novel positive detection system of in vivo mutations in rpsL (strA) transgenic mice. Mutat Res.
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