The Sound of Evolution
Lorazepam
Mechanism of action:
Lorazepam is a benzodiazepine derivative. Lorazepam binds to the benzodiazepine-binding site on the GABA_A receptor and enhances the inhibitory effect of GABA_A receptor signaling. This increases the frequency of chloride channel opening, allowing chloride ions to enter neurons and causing membrane hyperpolarization, which produces anxiolytic, sedative-hypnotic, and anticonvulsant effects.
Reference(s):
1. Kemper N et al. (1980). Benzodiazepine dependence: addiction potential of the benzodiazepines is greater than previously assumed. Dtsch Med Wochenschr.
2. Lader M et al. (1984). Short-term versus long-term benzodiazepine therapy. Curr Med Res Opin.
3. Maltais F et al. (1996). A randomized, double-blind, placebo-controlled study of lorazepam as premedication for bronchoscopy. Chest.