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The Sound of Evolution
Molindone
Mechanism of action:
Molindone is an indolone derivative. Molindone primarily antagonizes dopamine D₂ receptors in the mesolimbic pathway, reducing the aberrant salience caused by excessive dopamine signaling, thereby decreasing delusions and hallucinations.
Reference(s):
1. Seeman P et al. (1998). Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors. Mol Psychiatry.
2. Lidow MS et al. (1997). Differential regulation of D2 and D4 dopamine receptor mRNAs in the primate cerebral cortex vs. neostriatum: effects of chronic treatment with typical and atypical antipsychotic drugs. J Pharmacol Exp Ther.
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