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The Sound of Evolution
Nadolol
Mechanism of action:
Nadolol is a non-selective β-adrenergic blocker. Nadolol antagonizes both β₁ and β₂ receptors. For example, blockade of β₁ receptors in the heart reduces myocardial contractility and cardiac output, while blockade of β₂ receptors in the airways can cause bronchoconstriction.
Reference(s):
1. Cernecka H et al. (2014). The odd sibling: features of beta3-adrenoceptor pharmacology. Mol Pharmacol.
2. Schafer-Korting M et al. (1984). Pharmacokinetics of nadolol in healthy subjects. Eur J Clin Pharmacol.
3. Morrison RA et al. (1988). Dose proportionality of nadolol pharmacokinetics after intravenous administration to healthy subjects. Eur J Clin Pharmacol.
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