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The Sound of Evolution
Nicardipine
Mechanism of action:
Nicardipine is a second-generation dihydropyridine calcium channel blocker. Nicardipine blocks L-type calcium channels in peripheral arterial vascular smooth muscle, preventing calcium ions from entering the cytoplasm. As a result, smooth muscle cannot contract, leading to peripheral arterial dilation and a reduction in blood pressure.
Reference(s):
1. Chen X et al. (2002). TTD: Therapeutic Target Database. Nucleic Acids Res.
2. Striessnig J et al. (2004). Ca²⁺ channel blockers. In Encyclopedic reference of molecular pharmacology. Berlin: Springer.
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