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The Sound of Evolution
Nifedipine
Mechanism of action:
Nifedipine is a calcium channel blocker and a dihydropyridine derivative. Nifedipine primarily acts on vascular smooth muscle cells by blocking L-type calcium channels, reducing the influx of calcium ions into the cytoplasm. This causes vascular smooth muscle relaxation and lowers blood pressure.
Reference(s):
1. Otto J et al. (1986). Protein binding of nifedipine. J Pharm Pharmacol.
2. Chung M et al. (1987). Clinical pharmacokinetics of nifedipine gastrointestinal therapeutic system. A controlled-release formulation of nifedipine. Am J Med.
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