The Sound of Evolution
Orciprenaline/Metaproterenol
Mechanism of action:
Orciprenaline is a bronchodilator and a selective beta2-adrenergic receptor agonist. Orciprenaline activates beta2-adrenergic receptors on airway smooth muscle. Through coupling with Gs proteins, it activates adenylyl cyclase, increases cAMP levels, lowers cytoplasmic calcium concentration, and causes bronchial smooth muscle relaxation.
Reference(s):
1. Kimura M et al. (1999). Stimulation by transforming growth factor-alpha of DNA synthesis and proliferation of adult rat hepatocytes in primary cultures: modulation by alpha- and beta-adrenoceptor agonists. J Pharmacol Exp Ther.
2. Gelmont DM et al. (1988). Hypokalemia induced by inhaled bronchodilators. Chest.
3. Fitch KD et al. (1986). The use of anti-asthmatic drugs. Do they affect sports performance? Sports Med.