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The Sound of Evolution
Pentoxyverine/Carbetapentane citrate
Mechanism of action:
Pentoxyverine is a non-opioid antitussive agent. The mechanism of action of Pentoxyverine remains unclear, but it is known to act on the cough center in the medulla, raising the cough reflex threshold and reducing responsiveness to stimulation.
Reference(s):
1. Dicpinigaitis PV et al. (2014). Antitussive drugs--past, present, and future. Pharmacol Rev.
2. Brown C et al. (2004). Antitussive activity of sigma-1 receptor agonists in the guinea-pig. Br J Pharmacol.
3. Deisemann H et al. (2008). Effects of common antitussive drugs on the hERG potassium channel current. J Cardiovasc Pharmacol.
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