The Sound of Evolution
Quazepam
Mechanism of action:
Quazepam is a benzodiazepine derivative. Quazepam binds to the benzodiazepine binding site on GABA_A receptors in the central nervous system, thereby enhancing GABAergic inhibitory activity. When GABA binds to these receptors, chloride (Cl-) channels open, causing hyperpolarization of the neuronal membrane. This reduces neuronal excitability and diminishes excessive activation in the limbic system and cerebral cortex.
Reference(s):
1. Miura M et al. (2004). In vitro metabolism of quazepam in human liver and intestine and assessment of drug interactions. Xenobiotica.
2. Zampaglione N et al. (1985). Disposition and metabolic fate of 14C-quazepam in man. Drug Metab Dispos.
3. Griffin CE 3rd et al. (2013). Benzodiazepine pharmacology and central nervous system-mediated effects. Ochsner J.