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Rivaroxaban


Mechanism of action:

Rivaroxaban is a direct factor Xa inhibitor. During coagulation, factor Xa is responsible for converting prothrombin into thrombin. Thrombin then converts fibrinogen into fibrin, resulting in thrombus formation. Rivaroxaban reversibly inhibits the function of factor Xa, reducing thrombin generation and fibrin formation and thereby lowering the likelihood of thrombus formation.

Reference(s):

1. Piccini JP et al. (2008). Rivaroxaban, an oral direct factor Xa inhibitor. Expert Opin Investig Drugs. 


2. Alban S et al. (2008). Pharmacological strategies for inhibition of thrombin activity. Curr Pharm Des. 


3. Stevenson M et al. (2009). Rivaroxaban for the prevention of venous thromboembolism: a single technology appraisal. Health Technol Assess.

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