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Sevoflurane


Mechanism of action:

Sevoflurane is a fluorinated ether compound. Sevoflurane positively modulates GABA_A receptor function, enhances chloride channel opening, causes hyperpolarization of the neuronal membrane potential, lowers the probability of neuronal firing, and produces sedation and loss of consciousness. Sevoflurane can also inhibit some NMDA receptors and other excitatory glutamate receptors, reduce calcium influx, and decrease synchronization and excitatory transmission within neural networks.

Reference(s):

1. Behne M et al. (1999). Clinical pharmacokinetics of sevoflurane. Clin Pharmacokinet. 


2. Wissing H et al. (2000). Pharmacokinetics of inhaled anaesthetics in a clinical setting: comparison of desflurane, isoflurane and sevoflurane. Br J Anaesth.

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