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The Sound of Evolution
Travoprost
Mechanism of action:
Travoprost is a prostaglandin F2α analog. It is a prodrug that, after corneal absorption, is hydrolyzed within the eye into its active form, travoprost acid. Travoprost acid selectively binds to prostaglandin F receptors in the iris and ciliary body, triggering extracellular matrix remodeling, such as collagen reorganization, which lowers resistance in the uveoscleral outflow pathway and thereby increases aqueous humor drainage.
Reference(s):
1. Waugh J et al. (2002). Travoprost. Drugs Aging.
2. Whitson JT et al. (2002). Travoprost--a new prostaglandin analogue for the treatment of glaucoma. Expert Opin Pharmacother.
3. Al-Jazzaf AM et al. (2003). Travoprost: a potent ocular hypotensive agent. Drugs Today (Barc).
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