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The Sound of Evolution
Trimipramine
Mechanism of action:
Trimipramine is a tricyclic antidepressant and a dibenzazepine derivative. It mainly antagonizes central H1 histamine receptors and 5-HT2A/5-HT2C receptors, thereby producing sedative and anxiety-reducing effects. Its inhibitory effects on the serotonin transporter and norepinephrine transporter are relatively weak.
Reference(s):
1. Diamond M et al. (2006). Antidepressants suppress production of the Th1 cytokine interferon-gamma, independent of monoamine transporter blockade. Eur Neuropsychopharmacol.
2. Tatsumi M et al. (1997). Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol.
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