The Sound of Evolution
Zolpidem
Mechanism of action:
Zolpidem is an imidazopyridine derivative. It binds to the benzodiazepine binding site on the GABA_A receptor and has high selectivity for receptors containing the α₁ subunit (BZ₁/ω₁). In the presence of GABA binding to the receptor, zolpidem increases the frequency of chloride channel opening, allowing chloride ions to enter neurons. This causes membrane hyperpolarization and enhances inhibition of central nervous system activity.
Reference(s):
1. Lemmer B et al. (2007). The sleep-wake cycle and sleeping pills. Physiol Behav.
2. Depoortere H et al. (1986). Zolpidem, a novel nonbenzodiazepine hypnotic. I. Neuropharmacological and behavioral effects. J Pharmacol Exp Ther.
3. Clauss RP et al. (2000). Extraordinary arousal from semi-comatose state on zolpidem. A case report. S Afr Med J.