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Abatacept

阿巴西普

Mechanism of action:

Abatacept 與抗原呈現細胞表面的 CD80/CD86 結合，防止與 T 細胞的 CD28 結合，從而抑制 T 細胞活化與細胞激素釋放。

​Reference(s):

1. Scheinfeld N et al. (2006). Abatacept: A review of a new biologic agent for refractory rheumatoid arthritis for dermatologists. J Dermatolog Treat. 


2. Vincenti F et al. (2007). T cell costimulation: a rational target in the therapeutic armamentarium for autoimmune diseases and transplantation. Annu Rev Med. 


3. Kremer JM et al. (2005). Selective costimulation modulators: a novel approach for the treatment of rheumatoid arthritis. J Clin Rheumatol.

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