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Albendazole

阿苯達唑

Mechanism of action:

Albendazole 能與寄生蟲細胞內的微管蛋白（β-tubulin）結合，抑制微管的聚合形成，導致細胞骨架功能喪失、葡萄糖吸收受阻與能量耗竭，最終使寄生蟲死亡。此作用相較於寄生蟲細胞，對宿主細胞之微管功能影響較低。

​Reference(s):

1. Lee E et al. (2015). Danazol inhibits cytochrome P450 2J2 activity in a substrate-independent manner. Drug Metab Dispos. 


2. Wu Z et al. (2013). CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems. Antimicrob Agents Chemother. 


3. Lee CA et al. (2012). Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity. Drug Metab Dispos.

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