The Sound of Evolution
Amlodipine
氨氯地平
Mechanism of action:
Amlodipine 是一種二氫吡啶類鈣離子通道阻斷劑（dihydropyridine calcium channel blocker）。Amlodipine 選擇性抑制血管平滑肌細胞膜上的 L 型鈣離子通道（L-type Ca²⁺ channel），減少鈣離子進入細胞內。因為細胞內 Ca²⁺ 濃度下降，肌動蛋白與肌球蛋白的交互作用減弱，導致血管平滑肌放鬆，使外週血管阻力降低與冠狀動脈擴張。
Reference(s):
1. Katoh M et al. (2000). Inhibitory potencies of 1,4-dihydropyridine calcium antagonists to P-glycoprotein-mediated transport: comparison with the effects on CYP3A4. Pharm Res.
2. Darvari R et al. (2004). Concentration dependency of modulatory effect of amlodipine on P-glycoprotein efflux activity of doxorubicin—a comparison with tamoxifen. J Pharm Pharmacol.
3. Kuzuya T et al. (2003). Amlodipine, but not MDR1 polymorphisms, alters the pharmacokinetics of cyclosporine A in Japanese kidney transplant recipients. Transplantation.