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Cefdinir

頭孢地尼

Mechanism of action:

Cefdinir 是一種第三代口服頭孢菌素抗生素（third-generation cephalosporin antibiotic）。Cefdinir 的 β-內醯胺（β-lactam）環可與細菌的青黴素結合蛋白（penicillin-binding proteins，PBPs）結合，抑制其轉肽酶（transpeptidase）活性，使肽聚醣（peptidoglycan）鏈無法交聯，最後細胞壁結構脆弱，因滲透壓而讓細菌裂解死亡。

​Reference(s):

1. Kimura Y et al. (2001). Successful steroid therapy for cefdinir-induced acute tubulointerstitial nephritis with progressive renal failure. Intern Med. 


2. Perry CM et al. (2004). Cefdinir: a review of its use in the management of mild-to-moderate bacterial infections. Drugs. 


3. Guay DR et al. (2000). Pharmacodynamics and pharmacokinetics of cefdinir, an oral extended spectrum cephalosporin. Pediatr Infect Dis J.

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