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Duloxetine

度洛西汀

Mechanism of action:

Duloxetine 是一種血清素-正腎上腺素回收抑制劑（serotonin-norepinephrine reuptake inhibitor）。Duloxetine 可選擇性抑制突觸前神經元的血清素轉運體（serotonin transporter）與正腎上腺素轉運體（norepinephrine transporter），使突觸間隙的血清素（serotonin）與正腎上腺素（norepinephrine）無法回收，增強兩者在中樞神經的傳導作用，進而調節與情緒、焦慮、睡眠與下行性疼痛抑制路徑相關的神經訊號。

​Reference(s):

1. Turcotte JE et al. (2001). Assessment of the serotonin and norepinephrine reuptake blocking properties of duloxetine in healthy subjects. Neuropsychopharmacology. 


2. Anttila S et al. (2002). Duloxetine Eli Lilly. Curr Opin Investig Drugs. 


3. Karpa KD et al. (2002). Duloxetine pharmacology: profile of a dual monoamine modulator. CNS Drug Rev.

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