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Folic acid

葉酸

Mechanism of action:

Folic acid 是維生素 B₉，在 DNA 合成、細胞分裂與造血功能中扮演重要角色。Folic acid 進入體內後，先由二氫葉酸還原酶（dihydrofolate reductase）還原為二氫葉酸（dihydrofolic acid），再進一步轉化為四氫葉酸（tetrahydrofolic acid）。四氫葉酸及其衍生物可參與嘌呤（purine）合成、胸苷酸（dTMP）合成、胺基酸代謝等。

​Reference(s):

1. Kamen B et al. (1997). Folate and antifolate pharmacology. Semin Oncol. 


2. Fenech M et al. (1998). Folate, vitamin B12, homocysteine status and DNA damage in young Australian adults. Carcinogenesis. 


3. Zittoun J et al. (1993). Anemias due to disorder of folate, vitamin B12 and transcobalamin metabolism. Rev Prat.

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