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Ketoconazole

酮康唑

Mechanism of action:

Ketoconazole 是一種咪唑類（imidazole）衍生物。Ketoconazole 能抑制黴菌的羊毛甾醇-14α-脫甲基酶（lanosterol 14α-demethylase，CYP51），該酵素負責將羊毛固醇（lanosterol）轉化為麥角固醇（ergosterol）。當此步驟被阻斷，黴菌的細胞膜結構會變得不完整，且羊毛固醇因為無法轉化而不斷堆積，引起毒性，最終讓真菌生長受抑或死亡。

​Reference(s):

1. Goeders NE et al. (1998). Ketoconazole reduces low dose cocaine self-administration in rats. Drug Alcohol Depend. 


2. Berwaerts J et al. (1999). Cushing's syndrome in pregnancy treated by ketoconazole: case report and review of the literature. Gynecol Endocrinol. 


3. Kazy Z et al. (2005). Population-based case-control study of oral ketoconazole treatment for birth outcomes. Congenit Anom (Kyoto).

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