The Sound of Evolution
Lomefloxacin
洛美沙星
Mechanism of action:
Lomefloxacin 是第二代氟喹諾酮類（fluoroquinolone）抗生素，屬於 DNA 旋轉酶（DNA gyrase，細菌的拓撲異構酶 II，topoisomerase II）的抑制劑。Lomefloxacin 會與 DNA 旋轉酶-DNA 複合體結合，使 DNA 旋轉酶產生的斷裂 DNA 無法被重新接合，導致DNA 斷裂累積，DNA 複製與轉錄停止，最終細菌死亡。（亦可抑制拓撲異構酶 IV，topoisomerase IV）
Reference(s):
1. Takenouchi T et al. (1995). Incidence of various gyrA mutants in 451 Staphylococcus aureus strains isolated in Japan and their susceptibilities to 10 fluoroquinolones. Antimicrob Agents Chemother.
2. Drusano GL et al. (1993). Pharmacodynamics of a fluoroquinolone antimicrobial agent in a neutropenic rat model of Pseudomonas sepsis. Antimicrob Agents Chemother.
3. Gushchin AE et al. (1999). Role of mutations in parC and gyrA in forming resistance of Mycoplasma hominis to fluoroquinolones. Mol Gen Mikrobiol Virusol.