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Loratadine

氯雷他定

Mechanism of action:

Loratadine 是一種第二代選擇性 H₁ 受體拮抗劑（selective H₁ receptor antagonist）。組織胺與 H₁ 受體結合後，會引起血管擴張、微血管通透性增加、感覺神經刺激（搔癢、打噴嚏）。Loratadine 能競爭性拮抗 H₁ 受體，阻斷上述反應，能減少鼻水、打噴嚏、鼻癢、緩解皮膚紅腫與搔癢。

​Reference(s):

1. See S et al. (2003). Desloratadine for allergic rhinitis. Am Fam Physician. 


2. Menardo JL et al. (1997). A review of loratadine in the treatment of patients with allergic bronchial asthma. Clin Ther. 


3. Howarth PH et al. (1990). Histamine and asthma: an appraisal based on specific H1-receptor antagonism. Clin Exp Allergy.

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