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The Sound of Evolution
Metoprolol
美托洛爾
Mechanism of action:
Metoprolol 是一種選擇性 β₁-腎上腺素受體阻斷劑（β₁-adrenergic selective blocker）。Metoprolol 主要作用於心肌與心臟傳導系統的 β₁ 受體，阻斷正腎上腺素（norepinephrine）與腎上腺素（epinephrine）與之結合，減弱交感神經訊號，導致心跳速率下降、心肌收縮力下降、房室傳導速度減慢等。
Reference(s):
1. Silberstein SD et al. (2015). Preventive Migraine Treatment. Continuum (Minneap Minn).
2. Bahar MA et al. (2018). The impact of CYP2D6 mediated drug-drug interaction: a systematic review on a combination of metoprolol and paroxetine/fluoxetine. Br J Clin Pharmacol.
3. Regardh CG et al. (1981). Pharmacokinetics of metoprolol in patients with hepatic cirrhosis. Clin Pharmacokinet.
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