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Miltefosine

米替福新

Mechanism of action:

Miltefosine 是一種磷脂類烷基磷酸膽鹼（alkylphosphocholine）衍生物。 Miltefosine 能插入寄生蟲細胞膜，使寄生蟲的膜結構不穩定、膜通透性異常、離子平衡受破壞，導致寄生蟲對滲透壓與氧化壓力更脆弱。Miltefosine 也會抑制磷脂醯膽鹼生成（phosphatidylcholine biosynthesis），抑制蛋白激酶 C（protein kinase C）的活性等，讓寄生蟲生長停滯與細胞功能失調。

​Reference(s):

1. Monge-Maillo B et al. (2015). Miltefosine for visceral and cutaneous leishmaniasis: drug characteristics and evidence-based treatment recommendations. Clin Infect Dis. 


2. Dorlo TP et al. (2008). Pharmacokinetics of miltefosine in Old World cutaneous leishmaniasis patients. Antimicrob Agents Chemother. 


3. Dorlo TP et al. (2012). Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis. J Antimicrob Chemother.

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