The Sound of Evolution
Nafcillin
萘夫西林
Mechanism of action:
Nafcillin 是一種 β-內醯胺類抗生素（β-lactam antibiotic），屬於抗葡萄球菌青黴素（antistaphylococcal penicillin）衍生物。Nafcillin 能與青黴素結合蛋白（penicillin-binding proteins，PBPs）結合，抑制肽聚醣（peptidoglycan）交聯，使細胞壁失去結構完整性，最終細菌因無法承受滲透壓而破裂死亡。
Reference(s):
1. Blumenthal KG et al. (2015). Improving Clinical Outcomes in Patients With Methicillin-Sensitive Staphylococcus aureus Bacteremia and Reported Penicillin Allergy. Clin Infect Dis.
2. Viehman JA et al. (2016). Adverse Events Lead to Drug Discontinuation More Commonly among Patients Who Receive Nafcillin than among Those Who Receive Oxacillin. Antimicrob Agents Chemother.
3. Youngster I et al. (2014). Comparative evaluation of the tolerability of cefazolin and nafcillin for treatment of methicillin-susceptible Staphylococcus aureus infections in the outpatient setting. Clin Infect Dis.