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The Sound of Evolution
Pimozide
哌迷清
Mechanism of action:
Pimozide 是一種二苯丁基哌啶類（diphenylbutylpiperidine）衍生物。Pimozide 能阻斷在基底核（basal ganglia）與邊緣系統（limbic system）的多巴胺 D₂ 受體（dopamine D₂ receptor），阻斷多巴胺在這些區域的作用。在妥瑞氏症中，多巴胺訊號被認為過度活化，pimozide 透過拮抗 D₂ 受體，抑制異常運動神經迴路的放電。
Reference(s):
1. Chen X et al. (2002). TTD: Therapeutic Target Database. Nucleic Acids Res.
2. Seeman P et al. (2002). Atypical antipsychotics: mechanism of action. Can J Psychiatry.
3. Silva MR et al. (2003). Pimozide injections into the Nucleus accumbens disrupt maternal behaviour in lactating rats. Pharmacol Toxicol.
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