The Sound of Evolution
Prazosin
哌唑嗪
Mechanism of action:
Prazosin 是一種選擇性 α₁-腎上腺素受體阻斷劑（selective α₁-adrenergic receptor antagonist）。正常情況下，α₁ 受體活化會透過 Gq/11 偶聯使 IP₃/DAG 上升，導致細胞質鈣離子濃度上升、蛋白激酶 C（protein kinase C）活化，引起血管平滑肌收縮。Prazosin 阻斷此受體後，會使血管平滑肌放鬆，讓週邊血管阻力下降。
Reference(s):
1. Bawaskar HS et al. (2007). Utility of scorpion antivenin vs prazosin in the management of severe Mesobuthus tamulus (Indian red scorpion) envenoming at rural setting. J Assoc Physicians India.
2. Cushman WC et al. (2002). Success and predictors of blood pressure control in diverse North American settings: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). J Clin Hypertens (Greenwich).
3. Hiraoka Y et al. (2003). Pharmacological characterization of unique prazosin-binding sites in human kidney. Naunyn Schmiedebergs Arch Pharmacol.