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Prednisolone

潑尼松龍

Mechanism of action:

Prednisolone 是一種合成型糖皮質類固醇（synthetic glucocorticoid）。Prednisolone 為脂溶性分子，可自由穿過細胞膜，在細胞質中與糖皮質激素受體（glucocorticoid receptor）結合後，形成配體-受體複合體，並移動進入細胞核，上調抗發炎基因（如 annexin A1）的表達量；抑制促發炎基因（如 IL-1、IL-2、IL-6、TNF-α）的表達量。

​Reference(s):

1. Pickup ME et al. (1979). Clinical pharmacokinetics of prednisone and prednisolone. Clin Pharmacokinet. 


2. Ferry JJ et al. (1988). Relative and absolute bioavailability of prednisone and prednisolone after separate oral and intravenous doses. J Clin Pharmacol. 


3. Matabosch X et al. (2015). Detection and characterization of prednisolone metabolites in human urine by LC-MS/MS. J Mass Spectrom.

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