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Quazepam

夸西泮

Mechanism of action:

Quazepam 是一種苯二氮平類（benzodiazepine）衍生物。Quazepam 結合於中樞神經系統 GABA_A 受體上的苯二氮平結合位點，以增強 GABAergic 的抑制作用。當 GABA 與這些受體結合時，氯離子（Cl⁻）通道開啟，使神經元膜超極化（hyperpolarization），導致神經元興奮性下降，降低邊緣系統與大腦皮質的過度活化。

​Reference(s):

1. Miura M et al. (2004). In vitro metabolism of quazepam in human liver and intestine and assessment of drug interactions. Xenobiotica. 


2. Zampaglione N et al. (1985). Disposition and metabolic fate of 14C-quazepam in man. Drug Metab Dispos. 


3. Griffin CE 3rd et al. (2013). Benzodiazepine pharmacology and central nervous system-mediated effects. Ochsner J.

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