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Sunitinib

舒尼替尼

Mechanism of action:

Sunitinib 是一種多標靶受體酪胺酸激酶抑制劑（multi-target receptor tyrosine kinase inhibitor）。Sunitinib 可抑制多種受體型酪胺酸激酶（tyrosine kinase），包括 VEGFR-1/VEGFR-2/VEGFR-3（血管內皮生長因子受體）、PDGFR-α/PDGFR-β（血小板衍生生長因子受體），抑制腫瘤血管新生。

​Reference(s):

1. Motzer RJ et al. (2007). Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 


2. Demetri GD et al. (2006). Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet.

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