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Vancomycin

萬古黴素

Mechanism of action:

Vancomycin 是一種醣胜肽類抗生素（glycopeptide antibiotic）。Vancomycin 會高親和力地結合於細菌細胞壁肽聚醣前驅物末端的 D-alanyl-D-alanine 結構，阻止轉醣苷作用（transglycosylation），間接抑制轉肽基反應（transpeptidation），使細胞壁無法正常形成，導致細菌結構不穩定、滲透壓失衡，最終細菌裂解死亡。

​Reference(s):

1. Levine DP et al. (2006). Vancomycin: a history. Clin Infect Dis. 


2. Small PM et al. (1990). Vancomycin for Staphylococcus aureus endocarditis in intravenous drug users. Antimicrob Agents Chemother. 


3. Gonzalez C et al. (1999). Bacteremic pneumonia due to Staphylococcus aureus: A comparison of disease caused by methicillin-resistant and methicillin-susceptible organisms. Clin Infect Dis.

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