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The Sound of Evolution
Abacavir
Mechanism of action:
Abacavir is converted by cellular enzymes after entering the cell into carbovir triphosphate. This molecule is structurally similar to deoxyguanosine-5'-triphosphate (dGTP) and competes with it. However, because carbovir triphosphate lacks a 3'-OH group, it terminates viral reverse transcriptase-mediated DNA synthesis.
Reference(s):
Yuen GJ et al. (2008). A review of the pharmacokinetics of abacavir. Clin Pharmacokinet.
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