The Sound of Evolution
Abarelix
Mechanism of action:
Abarelix is a gonadotropin-releasing hormone antagonist and belongs to the class of synthetic peptides. Abarelix binds to gonadotropin-releasing hormone receptors in the anterior pituitary, preventing endogenous gonadotropin-releasing hormone from interacting with its receptor and thereby suppressing the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Once luteinizing hormone secretion is suppressed, testosterone synthesis by Leydig cells in the testes is markedly reduced.
Reference(s):
1. Debruyne FM et al. (2004). Gonadotropin-releasing hormone antagonist in the management of prostate cancer. Rev Urol.
2. Jiang G et al. (2001). GnRH antagonists: a new generation of long acting analogues incorporating p-ureido-phenylalanines at positions 5 and 6. J Med Chem.
3. Liu T et al. (2025). BindingDB in 2024: a FAIR knowledgebase of protein-small molecule binding data. Nucleic Acids Res.