top of page
The Sound of Evolution
Abatacept
Mechanism of action:
Abatacept binds to CD80/CD86 on the surface of antigen-presenting cells, preventing their interaction with CD28 on T cells, thereby inhibiting T-cell activation and cytokine release.
Reference(s):
1. Scheinfeld N et al. (2006). Abatacept: A review of a new biologic agent for refractory rheumatoid arthritis for dermatologists. J Dermatolog Treat.
2. Vincenti F et al. (2007). T cell costimulation: a rational target in the therapeutic armamentarium for autoimmune diseases and transplantation. Annu Rev Med.
3. Kremer JM et al. (2005). Selective costimulation modulators: a novel approach for the treatment of rheumatoid arthritis. J Clin Rheumatol.
bottom of page