top of page
The Sound of Evolution
Acamprosate
Mechanism of action:
The exact mechanism of acamprosate remains unclear. In the central nervous system, it may interact with the neurotransmitter systems of glutamate and GABA, modulating the dynamic balance between glutamatergic and GABAergic signaling. This regulatory effect is thought to be related to the adaptive changes in the central nervous system associated with alcohol dependence.
Reference(s):
Antonescu IE et al. (2020). Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions. Pharmaceutics.
bottom of page