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The Sound of Evolution
Acebutolol
Mechanism of action:
When norepinephrine and epinephrine bind to β₁ receptors in the heart, they increase heart rate and blood pressure. Acebutolol is a β₁ receptor blocker that inhibits the effects of norepinephrine and epinephrine.
Reference(s):
1. Troutman MD et al. (2003). Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharm Res.
2. Terao T et al. (1996). Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier. J Pharm Pharmacol.
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