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The Sound of Evolution
Acenocoumarol
Mechanism of action:
Acenocoumarol inhibits the activity of vitamin K epoxide reductase in the liver, thereby blocking the regeneration of vitamin K. As a result, the synthesis of clotting factors II, VII, IX, and X is suppressed, reducing the blood's ability to coagulate.
Reference(s):
Saraeva RB et al. (2007). Pharmacogenetics of acenocoumarol: CYP2C9, CYP2C19, CYP1A2, CYP3A4, CYP3A5 and ABCB1 gene polymorphisms and dose requirements. J Clin Pharm Ther.
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