The Sound of Evolution
Acetaminophen
Mechanism of action:
Acetaminophen inhibits prostaglandin synthesis pathways in the central nervous system, specifically cyclooxygenase (COX) pathways, thereby reducing prostaglandin production, relieving mild to moderate pain, and lowering fever. However, its inhibitory effect on this pathway in peripheral tissues is relatively weak. It is still unclear which specific protein within this pathway acetaminophen targets.
Reference(s):
1. Wang E et al. (2001). Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. Chem Res Toxicol.
2. Faassen F et al. (2003). Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm.
3. Novak A et al. (2013). Acetaminophen inhibits intestinal p-glycoprotein transport activity. J Pharm Sci.