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The Sound of Evolution
Acetylsalicylic acid
Mechanism of action:
Acetylsalicylic acid exerts its main effect by irreversibly inhibiting cyclooxygenase (COX-1 and COX-2), thereby suppressing the synthesis of prostaglandins and thromboxane A₂.
Reference(s):
1. Parvez MM et al. (2017). Evaluation of para-Aminosalicylic Acid as a Substrate of Multiple Solute Carrier Uptake Transporters and Possible Drug Interactions with Nonsteroidal Anti-inflammatory Drugs In Vitro. Antimicrob Agents Chemother.
2. Wang C et al. (2014). Aspirin and probenecid inhibit organic anion transporter 3-mediated renal uptake of cilostazol and probenecid induces metabolism of cilostazol in the rat. Drug Metab Dispos.
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