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The Sound of Evolution
Adefovir
Mechanism of action:
Adefovir is converted inside infected cells into its active form, adefovir diphosphate. This active metabolite competitively inhibits the DNA polymerase of hepatitis B virus (HBV), and once incorporated into viral DNA, it causes chain termination because it lacks a 3'-OH group. As a result, viral replication is ultimately suppressed.
Reference(s):
Zhou Y et al. (2024). TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res.
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